PhD Student · Xiamen University
Buchao Zhan
AI for Science · Protein Intelligence · Computational Biology
I am a PhD student at Xiamen University. My research lies at the intersection of artificial intelligence and computational biology, with growing interests in protein foundation models, protein sequence–structure modeling, generative protein design, and AI for scientific discovery.
Research Interests
Protein Intelligence
- Protein foundation models
- Protein representation learning
- Sequence–structure modeling
- Protein language models
- Multimodal protein models
Generative Protein Design
- Structure-conditioned sequence design
- Inverse folding
- Generative protein models
- Protein design evaluation
- Robustness and uncertainty
AI for Scientific Discovery
- AI for Science
- Biological foundation models
- Scientific reasoning
- Knowledge-guided AI
- Scientific tool use
News
2026.02
Our paper Het2Gene: A Phenotype-Driven Model for Gene Prioritization by Heterogeneous Graph Embedding was accepted by Computers in Biology and Medicine.
2026.01
Our paper Consensus-on-Graph: Plan-Driven Exploration and Consensus Decision-Making on Knowledge Graphs was accepted by DASFAA 2026.
2025.11
Our paper FNatPred: A Data-Driven Approach for Distinguishing Between NAT and Tumor on the Fungal Microbiome was accepted by IEEE Transactions on Computational Biology and Bioinformatics.
2025.10
Our paper scCAVAE: Predicting Perturbation Responses by Modeling Synergistic Interactions with Attention and Hierarchical Supervised Contrastive Learning was accepted by IEEE BIBM 2025.
2025.06
Awarded Outstanding Master’s Graduate of Hainan University.
2024.09
Awarded the National Scholarship for Master’s Students at Hainan University.
Selected Publications
RARoK: Retrieval-Augmented Reasoning on Knowledge for Medical Question Answering
Text2SPARQL: Grammar Pre-training for Text-to-QDMR Semantic Parsers from Intermediate Question Decompositions
Augmented Mycobiome-Based Cancer Detection by an Interpretable Large Model
scCAVAE: Predicting Perturbation Responses by Modeling Synergistic Interactions with Attention and Hierarchical Supervised Contrastive Learning
Education
Current PhD
Xiamen University
PhD Student
Xiamen, China
2022–2025 M.Sc.
Hainan University
Master’s Degree
Haikou, China
2018–2022 B.Sc.
Yichun University
Undergraduate Degree
Yichun, China
Honors & Awards
2025.06
Outstanding Master’s Graduate, Hainan University
2024.09
National Scholarship for Master’s Students, Hainan University · Top 1%
Academic Talks
2024.12 · Auckland
International Conference on Neural Information Processing (ICONIP)
2024.12 · Lisbon
IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
2024.07 · Haikou
International Conference on Computational Intelligence and Applications
Industry Experience
2022.02–2022.05
Embedded Development Engineer Intern
CubyFun · Shenzhen, China
CubyFun · Shenzhen, China